Research themes in pediatric epileptology
The research themes are centered around the clinical activities of the department, and more particularly around epileptology, neurophysiology and cognitive neuroscience.
Our project revolves around:
-The problem of comorbidities associated with epilepsy and more specifically around cognitive disorders associated with childhood epilepsy, particularly attention disorders (ADHD).
-Clinical research on the natural history, pathophysiology and management of epileptic and neurodevelopmental encephalopathies (DEEs), often of genetic origin, in collaboration with the Neuropediatrics and Genetics Services as well as within the framework of collaborations national and international.
-Regular involvement in the evaluation of new molecules and diagnostic tests concerning epilepsy and DEEs.
-Clinical research concerning the diagnosis, management and therapy of patients with DEE associated with abnormal movements, such as Alternating Hemiplegia (HA) in children, within the framework of the International Research Consortium for ‘HA (IAHCRC) coordinated by Dr. Panagiotakaki
-Stratification of clinical, neurophysiological and imaging data to facilitate the deployment of machine learning/artificial intelligence for the diagnosis and prognosis of childhood epilepsy
-Presurgical evaluation of drug-resistant focal epilepsies in collaboration with the pediatric neurosurgery department, with phase 1 assessment (imaging and video-EEG) and phase 2 with Stereo-EEG. Current research project on high-resolution EEG and MEG in phase 1 and genetic analysis on resected tissues for diagnostic and prognostic purposes.
All of these activities are part of the activity of the National Reference Center for Rare Epilepsies (CREER) and the European Reference Network for Rare Epilepsies (ERN EPICARE)
Principales Collaborations:
– HCL : Epilepsie adulte; neurochirurgie de l’épilepsie ; troubles du sommeil ; génétique de l’épilepsie ; neuropédiatrie ; neuroimagerie
– Centres de recherche Lyon (CRNL) : équipes TIGER, EDUWELL, PAM
– Institut Neuromyogène (INMG): Pathophysiology and genetics of neuron and muscle (PNGM, G.Lesca)
1. Panagiotakaki, E., Tiziano, F. D., Mikati, M. A., Vijfhuizen, L. S., Nicole, S., Lesca, G., Abiusi, E., Novelli, A., Di Pietro, L., I.B.AHC Consortium, IAHCRC Consortium, Harder, A. V. E., Walley, N. M., De Grandis, E., Poulat, A. L., Portes, V. D., Lépine, A., Nassogne, M. C., Arzimanoglou, A., Vavassori, R., … Heinzen, E. L.
Exome sequencing of ATP1A3-negative cases of alternating hemiplegia of childhood reveals SCN2A as a novel causative gene. European journal of human genetics : EJHG, 32(2), 224–231. https://doi.org/10.1038/s41431-023-01489-4l
2. Patel, S., Maney, K., Morris, L., Papadopoulou, M. T., Prange, L., Boggs, A., Hunanyan, A., Megvinov, A., Vavassori, R., Panagiotakaki, E., & Mikati, M. A.
Real life retrospective study of cannabidiol therapy in alternating hemiplegia of childhood. European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, 49, 55–59. Advance online publication. https://doi.org/10.1016/j.ejpn.2024.02.004
3. Mancuso, M., Lopriore, P., Lamperti, C., Klopstock, T., Rahman, S., Licchetta, L., Kornblum, C., Wortmann, S. B., Dollfus, H., Papadopoulou, M. T., Arzimanoglou, A., Scarpa, M., Graessner, H., & Evangelista, T.
Current management of primary mitochondrial disorders in EU countries: the European Reference Networks survey. Journal of neurology, 271(2), 835–840. https://doi.org/10.1007/s00415-023-12017-1
4. Gokce-Samar, Z., Vetro, A., De Bellescize, J., Pisano, T., Monteiro, L., Penaud, N., Korff, C. M., Fluss, J., Marini, C., Cesaroni, E., Alvarez, B. M., Sanlaville, D., Chatron, N., Arzimanoglou, A. A., Labalme, A., Cuddapah, V. A., Ruggiero, S. M., Lecoquierre, F., Nicolas, G., Marie, G. A., … Lesca, G.
Molecular and Phenotypic Characterization of the RORB-Related Disorder. Neurology, 102(2), e207945. https://doi.org/10.1212/WNL.0000000000207945
5. Rheims S, Herbillon V, Gaillard S, et al.
Phosphatidylserine enriched with polyunsaturated n-3 fatty acid supplementation for attention-deficit hyperactivity disorder in children and adolescents with epilepsy: A randomized placebo-controlled trial. Epilepsia Open. Published online January 3, 2024. doi:10.1002/epi4.12892
6. Papadopoulou MT, Welniarz Q, Roubertie A, et al.
Effect of Oxygen Administration on Paroxysmal Motor Events in Alternating Hemiplegia of Childhood. Mov Disord. 2023;38(9):1759-1761. doi:10.1002/mds.29561
7. Neal, A., Bouet, R., Lagarde, S., Ostrowsky-Coste, K., Maillard, L., Kahane, P., Touraine, R., Catenoix, H., Montavont, A., Isnard, J., Arzimanoglou, A., Hermier, M., Guenot, M., Bartolomei, F., Rheims, S., & Jung, J.
Epileptic spasms are associated with increased stereo-electroencephalography derived functional connectivity in tuberous sclerosis complex. Epilepsia, 63(9), 2359–2370. https://doi.org/10.1111/epi.17353
8. Boulogne, S., Pizzo, F., Chatard, B., Roehri, N., Catenoix, H., Ostrowsky-Coste, K., Giusiano, B., Guenot, M., Carron, R., Bartolomei, F., & Rheims, S.
Functional connectivity and epileptogenicity of nodular heterotopias: A single-pulse stimulation study. Epilepsia, 63(4), 961–973. https://doi.org/10.1111/epi.17168
9. Ciumas C, Montavont A, Ilski F, et al.
Neural correlates of verbal working memory in children with epilepsy with centro-temporal spikes. Neuroimage Clin. 2020;28:102392. doi:10.1016/j.nicl.2020.102392e
10. Neal A, Ostrowsky-Coste K, Jung J, et al.
Epileptogenicity in tuberous sclerosis complex: A stereoelectroencephalographic study. Epilepsia. 2020;61(1):81-95. doi:10.1111/epi.16410
11. Arnaud, L., Abi Warde, M. T., Barcia, G., de Bellescize, J., Chatron, N., Faoucher, M., de Saint Martin, A., Héron, D., Jedraszak, G., Lacoste, C., Lèbre, A. S., Jenneson-Lyver, M., Labalme, A., Leguern, E., Mignot, C., Milh, M., Nabbout, R., Nava, C., Panagiotakaki, E., Piton, A., … Lesca, G.
The EPIGENE network: A French initiative to harmonize and improve the nationwide diagnosis of monogenic epilepsies. European journal of medical genetics, 65(3), 104445. https://doi.org/10.1016/j.ejmg.2022.104445
12. Barba, C., Cross, J. H., Braun, K., Cossu, M., Klotz, K. A., De Masi, S., Perez Jiménez, M. A., Gaily, E., Specchio, N., Cabral, P., Toulouse, J., Dimova, P., Battaglia, D., Freri, E., Consales, A., Cesaroni, E., Tarta-Arsene, O., Gil-Nagel, A., Mindruta, I., Di Gennaro, G., … Guerrini, R.
Trends in pediatric epilepsy surgery in Europe between 2008 and 2015: Country-, center-, and age-specific variation. Epilepsia, 61(2), 216–227. https://doi.org/10.1111/epi.16414
13. Gokce-Samar Z, Ostrowsky-Coste K, Gauthier-Morel D, et al.
Predictive factors and prognostic value for status epilepticus in newborns. Eur J Paediatr Neurol. 2019;23(2):270-279. doi:10.1016/j.ejpn.2019.01.006
