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Pr Laure Peter derex

Center for Sleep Medicine :

Hôpital de la Croix-Rousse – Hôpital Pierre Wertheimer

The Center for Sleep Medicine welcomes 15 patients daily for a wide range of diagnostic procedures, including polysomnography, vido-polysomnography, polygraphy, daytime vigilance tests, prolonged sleep recordings, actigraphy, and circadian rhythm assessments. It offers multidisciplinary care for a broad spectrum of sleep disorders, including hypersomnolence, sleep-related respiratory disorders, parasomnias, motor sleep disorders, circadian rhythm disturbances, and insomnia. In collaboration with the Pierre Wertheimer Neurological Hospital, the department is involved in the management of sleep disorders associated with neurological conditions such as epilepsy, stroke, and neurodegenerative or inflammatory diseases. The department is recognized as a Reference Centre for Narcolepsy and Rare Hypersomnias, in cooperation with pediatric sleep unit of Hôpital Femme Mère Enfant, and is affiliated with the National Reference Centre for Neuromuscular Diseases for the management of sleep-related respiratory disorders.

neuro-ophtamologie
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Narcolepsy
Pr-Claire-Haegelen

Pr Laure PETER DEREX

Team coordinator

CRNL PAM team member 

Other team members :

    – Dr F. Ricordeau (CRNL PAM)

    – Dr H. Bastuji (CRNL NEUROPAIN)

    – Dr P. Tankéré (CRNL PAM)

    – Dr E. Stauffer (LIBM VBRBC)

Main collaborations:

    – HCL : Epileptology unit ; pediatric sleep unit

    – CRNL : TIGER – SLEEP – WAKE – CMO – FORGETTING

Research themes

Sleep and sleep/wake transitions in physiological and pathophysiological conditions ; sleep structure as a biomarker for neurological diseases (PI : L. Peter-Derex)

  • Interactions between epilepsy and sleep (PI : L. Peter-Derex, S. Rheims, P. Ruby)
  • Neurophysiology and functions of dreams (PI : P. Ruby)
  • Non-pharmacological therapeutic approaches for narcolepsy (PI: L. Peter-Derex, K. Spiegel), insomnia (PI: B Putois), parasomnias (B. Putois, L. Peter-Derex)
  • Microstructural markers of sleep in neurological sleep disorders (PI L. Peter-Derex, J Nicolas)

Main ongoing projects

  1. SLEEPIE : prospective sleep cohort in recent-onset epilepsy (PI)
  2. CRIMES : Characterizing rapid rehearsal-induced memory consolidation and its modulation by sleep by combining fMRI and intracranial EEG (PI)
  3. EPIDREAM : Dreaming in patients with epilepsy (PI)
  4. NARCOFOOD : interaction between sleepiness, nighttime sleep and food intake in narcolepsy (PI)
  5. PEACH II : Prevention of epileptic seizures at the acute phase of intra-cerebral hemorrhage (partner)

Cohorts

SLEEPIE: prospective sleep cohort in recent-onset epilepsy (clinical and neurophysiological data)

Main national and international collaborations

National collaborations :

  • Regional (Clermont-Ferrand University Hospital: Professor Fantini; Grenoble University Hospital: Professor Tamisier; St Etienne University Hospital: Professor Roche)
  • National network of Centres of Reference/Competence for Rare Diseases of Narcolepsy and Hypersomnia.

International collaborations :

  • Montréal, Canada (McGill University/Concordia University : B Frauscher, N von Ellenrieder, J Gotman, C Grova)
  • Durham, NC, USA (Duke University: B Frauscher)
  • Budapest, Hungary (Eötvös Loránd University: P. Simor)
  • Stanford, USA (Stanford University: E Mignot)

Publications

1. Nicolas J, Comperat L, Fort P, et al. REM sleep microstructure alterations in REM sleep behavior disorder: beyond muscle tone. Sleep. Published online June 9, 2025:zsaf158. doi:10.1093/sleep/zsaf158

2. Charpentier-Hélary M, de la Chapelle A, Linard M, et al. Dreaming in patients with epilepsy: a cross-sectional cohort study. J Sleep Res. Published online January 31, 2025:e14464. doi:10.1111/jsr.14464

3. Peter-Derex L, von Ellenrieder N, van Rosmalen F, et al. Regional variability in intracerebral properties of NREM to REM sleep transitions in humans. Proc Natl Acad Sci U S A. 2023;120(26):e2300387120. doi:10.1073/pnas.2300387120

4. Peter-Derex L, Avigdor T, Rheims S, et al. Enhanced thalamocortical functional connectivity during rapid-eye-movement sleep sawtooth waves. Sleep. 2023;46(6):zsad097. doi:10.1093/sleep/zsad097

5. Peter-Derex L, Philippeau F, Garnier P, et al. Safety and efficacy of prophylactic levetiracetam for prevention of epileptic seizures in the acute phase of intracerebral haemorrhage (PEACH): a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet Neurol. 2022;21(9):781-791. doi:10.1016/S1474-4422(22)00235-6

6. Ruby P, Eskinazi M, Bouet R, Rheims S, Peter-Derex L. Dynamics of hippocampus and orbitofrontal cortex activity during arousing reactions from sleep: An intracranial electroencephalographic study. Hum Brain Mapp. 2021;42(16):5188-5203. doi:10.1002/hbm.25609

7. Frauscher B, von Ellenrieder N, Dolezalova I, Bouhadoun S, Gotman J, Peter-Derex L. Rapid Eye Movement Sleep Sawtooth Waves Are Associated with Widespread Cortical Activations. J Neurosci Off J Soc Neurosci. 2020;40(46):8900-8912. doi:10.1523/JNEUROSCI.1586-20.2020

8. Peter-Derex L, Klimes P, Latreille V, Bouhadoun S, Dubeau F, Frauscher B. Sleep Disruption in Epilepsy: Ictal and Interictal Epileptic Activity Matter. Ann Neurol. 2020;88(5):907-920. doi:10.1002/ana.25884

9. Putois B, Peter-Derex L, Leslie W, Braboszcz C, El-Hage W, Bastuji H. Internet-Based Intervention for Posttraumatic Stress Disorder: Using Remote Imagery Rehearsal Therapy to Treat Nightmares. Psychother Psychosom. 2019;88(5):315-316. doi:10.1159/000501105

10. Peter-Derex L, Magnin M, Bastuji H. Heterogeneity of arousals in human sleep: A stereo-electroencephalographic study. NeuroImage. 2015;123:229-244. doi:10.1016/j.neuroimage.2015.07.057