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Neurovascular

Vascular Neurology Department – ​​Pierre Wertheimer Hospital – Hospices Civils de Lyon

The vascular neurology department specializes in the management of strokes and transient ischemic attacks (TIAs). As a referral center equipped with a neurovascular intensive care unit and access to mechanical thrombectomy, it conducts clinical and translational research on stroke in collaboration with several research teams.

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neuro-ophtamologie

Pr Tae-Hee CHO

Pr Laura MECHTOUFF

Neurovascular team coordinators

IRIS team members

« Ischemia-ReperfusIon Syndromes (IRIS) »

CarMeN Laboratory (Cardiovascular, Metabolism, Diabetes, and Nutrition
Inserm U1060 / INRAE U1397 / Université Claude Bernard Lyon 1)

Other team members:

Main collaborations:

  • HCL : neuroradiologie, radiologie cardiovasculaire, cardiologie, chirurgie vasculaire, Neurobiotec, Centre d’Investigation Clinique CIC 1407, Cellule Recherche Imagerie, Pôle de Santé Publique ;
  • CREATIS ;
  • CERMEP ;
  • INRIA ;
  • RESHAPE ;
  • ERIC

Research themes

Research activities combine clinical and translational research across four main areas:

  • Pathophysiology and prognosis of stroke: inflammation, biological and imaging biomarkers, microbiota, and environmental determinants;
  • Imaging, multimodal data, and artificial intelligence, to better characterize strokes and predict prognosis and treatment response;
  • Acute-phase treatments and neuroprotection in ischemic stroke and intracerebral hemorrhage;
  • Prevention and post-stroke care pathways: atherosclerosis, cardiovascular and metabolic risk factors, etiological assessment, secondary prevention, and socio-territorial determinants.

Main ongoing projects

ANR CHITOSANNEUROPROTECT: development of an iron-chelating treatment for acute ischemic and hemorrhagic stroke (PI: T.-H. Cho).
ANR CMRO2: study of cerebral oxygen metabolism via MRI in ischemic stroke as a prognostic biomarker (PI: T.-H. Cho).
PHRC CONCISE: evaluation of a multimodal cardiac, cervical, and intracranial MRI approach for the etiological assessment of ischemic stroke and TIA (PI: L. Mechtouff).
PHRC PEACH II: evaluation of levetiracetam for the prevention of seizures during the acute phase of intracerebral hemorrhage (PI: L. Derex).
EQUITY-STROKE – SHAPE-Med: study of socioeconomic and territorial determinants of care and life trajectories following stroke (PI: L. Mechtouff).

Cohorts

HIBISCUS-STROKE: a prospective cohort of patients with ischemic stroke treated by thrombectomy, combining clinical, biological, and imaging data, with a biobank.

RELATE: a registry of patients with ischemic stroke treated by thrombolysis and/or thrombectomy.

Main national and international collaborations

NATIONAL COLLABORATIONS 

  • STROKELINK–F-CRIN Network;
  • Foch Hospital;
  • Fondation Adolphe de Rothschild Hospital / Université Paris Cité;
  • Grenoble Institute of Neurosciences

INTERNATIONAL COLLABORATIONS 

  • Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan (Italy) ;
  • Università degli Studi di Milano-Bicocca / Fondazione IRCCS San Gerardo dei Tintori, Monza (Italy) ;
  • University Medical Center Hamburg-Eppendorf, Hambourg (Germany)

Publications

1. Ong E, Clottes P, Leon C, et al. Mitochondria dysfunction, a potential cytoprotection target against ischemia-reperfusion injury in a mouse stroke model. Neurother J Am Soc Exp Neurother. 2025;22(2):e00549. doi:10.1016/j.neurot.2025.e00549

2. Clottes P, Benech N, Dumot C, Jarraud S, Vidal H, Mechtouff L. Gut microbiota and stroke: New avenues to improve prevention and outcome. Eur J Neurol. 2023;30(11):3595-3604. doi:10.1111/ene.15770

3. Bani-Sadr A, Mechtouff L, De Bourguignon C, et al. Blood-Brain Barrier Permeability and Kinetics of Inflammatory Markers in Acute Stroke Patients Treated With Thrombectomy. Neurology. 2023;101(5):e502-e511. doi:10.1212/WNL.0000000000207460

4. Mechtouff L, Debs N, Frindel C, et al. Association of Blood Biomarkers of Inflammation With Penumbra Consumption After Mechanical Thrombectomy in Patients With Acute Ischemic Stroke. Neurology. 2022;99(18):e2063-e2071. doi:10.1212/WNL.0000000000201038

5. Peter-Derex L, Philippeau F, Garnier P, et al. Safety and efficacy of prophylactic levetiracetam for prevention of epileptic seizures in the acute phase of intracerebral haemorrhage (PEACH): a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet Neurol. 2022;21(9):781-791. doi:10.1016/S1474-4422(22)00235-6

6. Bochaton T, Leboube S, Paccalet A, et al. Impact of Age on Systemic Inflammatory Profile of Patients With ST-Segment-Elevation Myocardial Infarction and Acute Ischemic Stroke. Stroke. 2022;53(7):2249-2259. doi:10.1161/STROKEAHA.121.036806

7. Mechtouff L, Sigovan M, Douek P, et al. Simultaneous assessment of microcalcifications and morphological criteria of vulnerability in carotid artery plaque using hybrid 18F-NaF PET/MRI. J Nucl Cardiol Off Publ Am Soc Nucl Cardiol. 2022;29(3):1064-1074. doi:10.1007/s12350-020-02400-0

8. Mechtouff L, Bochaton T, Paccalet A, et al. A lower admission level of interleukin-6 is associated with first-pass effect in ischemic stroke patients. J Neurointerventional Surg. 2022;14(3):248-251. doi:10.1136/neurintsurg-2021-017334

9. Mechtouff L, Bochaton T, Paccalet A, et al. Association of Interleukin-6 Levels and Futile Reperfusion After Mechanical Thrombectomy. Neurology. 2021;96(5):e752-e757. doi:10.1212/WNL.0000000000011268

10. Mechtouff L, Bochaton T, Paccalet A, et al. Matrix Metalloproteinase-9 and Monocyte Chemoattractant Protein-1 Are Associated With Collateral Status in Acute Ischemic Stroke With Large Vessel Occlusion. Stroke. 2020;51(7):2232-2235. doi:10.1161/STROKEAHA.120.029395