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Neuro-ophtalmology & Neuro-otology

Neuro-cognition and neuro-ophthalmology department

The service’s originality lies in its cross-cutting and integrative approach to neurology, centered on specific functions—vision, balance, and cognition—and on the continuity of care for adult patients, moving beyond the traditional compartmentalization of subspecialties. This approach enables comprehensive patient care, based on an alliance between the various partners in the healthcare network, whose multidisciplinary collaboration enriches everyone’s knowledge and practices. The patient’s approach is also transversal over time: pathologies affect all ages of adulthood and can be transient or chronic, thus requiring support throughout the life course. Beyond the benefits for patients, this multidisciplinary, comprehensive approach, and the diversity of pathologies treated make our service attractive to medical and paramedical students, residents, physicians, and non-medical staff.

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neuro-ophtamologie
Pr Caroline Froment

Pr Caroline FROMENT

Team coordinator

CRNL Impact team member

Other team membres :

    – Dr Ruben Hermann, MD, PhD, CRNL Impact

Main collaborationson the Lyon site :

– Laure Pisella, Centre de Recherche en Neurosciences de Lyon (CRNL) INSERM U1028, CNRS UMRS5292, Equipe Trajectoire

– Romain Marignier, Centre de Référence des Maladies Inflammatoires Rares du Cerveau et de la Moelle, Hôpital Neurologique Pierre Wertheimer, Bron, France

– Françoise Bouhour, Antoine Pégat, Pathologies neuromusculaires et du motoneurone

– Emmanuel Jouanneau, Romain Manet, Neurochirurgie de la base du crâne

Research themes

I belong to the Lyon Neuroscience Research Center (CRNL) INSERM U1028, CNRS UMRS5292, Impact Team (Integrative, Multisensory, Perception, Action and Cognition Team). My research projects focus on the pathophysiological understanding, clinical and functional evaluation, and therapeutic management of neuro-otological or neuro-ophthalmological manifestations of neurological disorders. For the past four years, my main project has concerned oculomotor adaptation in the context of vestibular areflexia, within the framework of my current supervision of a doctoral student.

Main ongoing projects

  1. Oculomotor adaptation in the context of vestibular areflexia (PI)
  2. KINE’HIT : Early physiotherapy and kinetics of compensatory saccades during an acute deficit in the Head Impulse Test (PI)
  3. Intracranial hypertension following dural tear closure (PI)
  4. Therapeutic trial in ocular myasthenia gravis (partner)
  5. Therapeutic trial in SCA27B (partner)

Main national and international collaborations

NATIONAL COLLABORATIONS

  • Catherine Vignal, Service de Neuro-Ophtalmologie, Fondation Rothshild, Paris

CONSORTIUM

  • International Clinical Consortium for NMOSD

INTERNATIONAL COLLABORATIONS

  • Aasef Shaikh, Department of Neurology, University Hospitals, Cleveland, USA
  • Axel Petzold, The National Hospital for Neurology and Neurosurgery, University College London, London, UK
  • Stefano Ramat, Department of Electrical, Computer and Biomedical Engineering, University of Pavia, Pavia, Italy

Publications

1. Petzold A, Fraser CL, Abegg M, et al. Diagnosis and classification of optic neuritis. Lancet Neurol. 2022;21(12):1120-1134. doi:10.1016/S1474-4422(22)00200-9

2. Shaikh AG, Kim JS, Froment C, et al. Scale for Ocular motor Disorders in Ataxia (SODA). J Neurol Sci. 2022;443:120472. doi:10.1016/j.jns.2022.120472

3. Cheviet A, Masselink J, Koun E, et al. Cerebellar signals drive motor adjustments and visual perceptual changes during forward and backward adaptation of reactive saccades. Cereb Cortex N Y N 1991. 2022;32(18):3896-3916. doi:10.1093/cercor/bhab455

4. Hermann R, Robert C, Lagadec V, Dupre M, Pelisson D, Froment Tilikete C. Catch-Up Saccades in Vestibular Hypofunction: A Contribution of the Cerebellum? Cerebellum Lond Engl. 2024;23(1):136-143. doi:10.1007/s12311-023-01512-w

5. Desoche C, Verdelet G, Salemme R, et al. Virtual reality set-up for studying vestibular function during head impulse test. Front Neurol. 2023;14:1151515. doi:10.3389/fneur.2023.1151515

6. Duvigneaud Z, Lardeux P, Verrecchia S, Benyahya L, Marignier R, Froment Tilikete C. Diagnostic criteria for optic neuritis in the acute and subacute phase: clinical uses and limitations. J Neurol. 2024;271(8):5629-5636. doi:10.1007/s00415-024-12540-9

7. Hermann R, Ramat S, Colnaghi S, et al. Catch-Up Saccades in Vestibulo-Ocular Reflex Deficit: Contribution of Visual Information? Ear Hear. 2025;46(3):719-728. doi:10.1097/AUD.0000000000001616

8. Thouvenot E, Laplaud D, Lebrun-Frenay C, et al. High-Dose Vitamin D in Clinically Isolated Syndrome Typical of Multiple Sclerosis: The D-Lay MS Randomized Clinical Trial. JAMA. 2025;333(16):1413-1422. doi:10.1001/jama.2025.1604

9. Dupré M, Hermann R, Vidoni L, et al. Impact of the intronic RFC1 expansion size in CANVAS phenotype: an oculomotor study. J Neurol. 2025;272(6):442. doi:10.1007/s00415-025-13150-9

10. Lagadec V, Pelisson D, Koun E, Robert C, Froment Tilikete C, Hermann R. Oculomotor compensatory strategies in bilateral vestibulopathy: Predictive and active conditions of head movements. J Vestib Res Equilib Orientat. 2025;35(6):290-299. doi:10.1177/095742712513551