Pr Laura MECHTOUFF
Neurovascular department
The vascular neurology department is dedicated to the emergency management of cerebrovascular accidents (CVA) and transient ischemic attacks (TIA).
Research areas
Pr Laura Mechtouff carries out clinical activity within the vascular neurology department (Head of department: Professor Tae-Hee Cho). She is particularly interested in the inflammatory phenomena that accompany cerebral infarction and their impact on the clinical prognosis of patients. As part of a science thesis, she sought to characterize the dynamics of this inflammatory response by studying the blood biomarkers of patients from a cohort that she coordinated as part of the RHU MARVELOUS (HIBISCUS-STROKE cohort: patients with cerebral infarction treated by thrombectomy). The objective of this work is to respond to the potential therapeutic issues linked to this mechanism in the context of future neuroprotection strategies. In this regard, Dr Mechtouff obtained funding to evaluate the effect of remote ischemic conditioning on lesion volume in patients treated by thrombectomy (PROTECT-I study). His research themes also include the assessment of cerebrovascular risk, atherothrombosis and prevention. All of his research and supervision work has led him to support his HDR in 2023.
National collaborations
– Alexandre Bani-Sadr, Yves Berthezène and Omer Faruk Eker, Neuroradiology Department, Pierre Wertheimer Neurological Hospital, Bron
– Thomas Bochaton, Cardiological emergency and cardiology intensive care department, Louis Pradel Cardiological Hospital, Bron
– Salim Si-Mohamed and Philippe Douek, Radiology Department, Louis Pradel Cardiological Hospital, Bron (CONCISE national PHRC)
– Nathan Mewton, CIC 1407 Clinical Investigation Center
– Nicolas Costes, CERMEP, Lyon
– Carole Frindel, CREATIS, INSERM U1206 & CNRS UMR 5220, Lyon
– Anne-Marie Schott and Julie Haesebaert, HESPER EA 7425, Lyon
– David Magne, ICBMS UMR CNRS 5246, Lyon
– National Stroke Clinical Research Network: STROKELINK
International collaborations
-Minor stroke Collaboration
-Stefano Fumagalli, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Department of Neuroscience, Milan, Italy (ERANET-NEURON 2019 STATEMENT)
Publications
1. Specific inflammatory profile of acute ischemic stroke patients with left atrial enlargement.
Front Cardiovasc Med 2023. Jul 19;10:1190857.
Fontaine J, Leboube S, Bochaton T, Thibault H, Amaz C, Cho TH, Paccalet A, Crola Da Silva C, Duhamel S, Buisson M, Rascle L, Bidaux G, Ovize M, Nighoghossian N, Mechtouff L.
2. Gut microbiota and stroke: New avenues to improve prevention and outcome.
Eur J Neurol. 2023 Mar 10, doi: 10.1111/ene.15770. Online ahead of print.
Clottes P, Benech N, Dumot C, Jarraud S, Vidal H, Mechtouff L.
3. Association of blood biomarkers of inflammation with penumbral growth after mechanical thrombectomy in patients with acute ischemic stroke.
Neurology. 2022 Nov 1;99(18):e2063-e2071.
Mechtouff L, Debs N, Frindel C, Bani-Sadr A, Bochaton T, Paccalet A, Crola Da Silva C, Buisson M, Amaz C, Berthezène Y, Faruk Eker O, Bouin M, de Bourguignon C, Mewton N, Ovize M, Bidaux G, Nighoghossian N, Cho TH.
4. Prognosis value of serum soluble ST2 level in acute ischemic stroke and STEMI patients in the era of mechanical reperfusion therapy.
J Neurol. 2022 May;269(5):2641-2648.
Mechtouff L, Paccalet A, Crola Da Silva C, Buisson M, Mewton N, Amaz C, Bonnefoy-Cudraz E, Leboube S, Cho TH, Nighoghossian N, Ovize M, Bochaton T
5. Large vessel cardioembolic stroke and embolic stroke of undetermined source share a common profile of matrix metalloproteinase-9 level and susceptibility vessel sign length.
Eur J Neurol. 2021 Jun;28(6):1977-1983.
Alhazmi H, Bani-Sadr A, Bochaton T, Paccalet A, Da Silva CC, Buisson M, Amaz C, Ameli R, Berthezene Y, Eker OF, Ovize M, Cho TH, Nighoghossian N, Mechtouff L.
6. A lower admission level of interleukin-6 is associated with first-pass effect in ischemic stroke patients.
J Neurointerv Surg. 2022;14(3):248-251.
Mechtouff L, Bochaton T, Paccalet A, Crola Da Silva C, Buisson M, Amaz C, Derex L, Ong E, Berthezene Y, Dufay N, Ovize M, Mewton N, Cho TH, Nighoghossian N, Eker OF.
7. Simultaneous assessment of microcalcifications and morphological criteria of vulnerability in carotid artery plaque using hybrid 18F-NaF PET/MRI.
J Nucl Cardiol. 2020 Nov 3.
Mechtouff L, Sigovan M, Douek P, Costes N, Le Bars D, Mansuy A, Haesebaert J, Bani-Sadr A, Tordo J, Feugier P, Millon A, Luong S, Si-Mohamed M, Collet-Benzaquen D, Canet-Soulas E, Bochaton T, Crola Da Silva C, Paccalet A, Magne D, Berthezene Y, Nighoghossian N.
8. Association of Interleukin-6 levels and futile reperfusion after mechanical thrombectomy.
Neurology. 2021 Feb 2;96(5):e752-e757.
Mechtouff L, Bochaton B, Paccalet A, Crola Da Silva C, Buisson M, Amaz C, Derex L, Ong E, Berthezene Y, Eker OF, Dufay N, Mewton N, Ovize M, Cho T-H, Nighoghossian N.
9. MMP-9 and MCP-1 are associated with collateral status in acute ischemic stroke with large vessel occlusion.
Stroke. 2020 Jul;51(7):2232-2235.
Mechtouff L, Bochaton B, Paccalet A, Crola Da Silva C, Buisson M, Amaz C, Derex L, Ong E, Berthezene Y, Eker OF, Dufay N, Mewton N, Ovize M, Cho T-H., Nighoghossian N.
10. Matrix metalloproteinase-9 relationship with infarct growth and hemorrhagic transformation in the era of thrombectomy.
Front Neurol. 2020 Jun 9;11:473.
Mechtouff L, Bochaton B, Paccalet A, Crola Da Silva C, Buisson M, Amaz C, Bouin M, Derex L, Ong E, Berthezene Y, Eker OF, Dufay N, Ovize M, Nighoghossian N, Cho T-H.
