Neurosurgery, basal cranium

Dr Timothée JACQUESSON has been carrying out neurosurgery activity on brain and skull base tumors since 2013. After a medical thesis on new endoscopic and microsurgical approaches to the petroclival region, he carried out science thesis work, supported in 2018, on the development of tractography applied to the detection of the position of cranial nerves displaced by tumors. He is today continuing his research work towards the automation of post-processing of MRI data to promote the routine clinical use of tractography and its derived tools (HDR 2022). It also seeks to use high-resolution diffusion MRI to help guide the histological diagnosis and extract the characteristics of complex skull base tumors (implantation, consistency, vascularization, cleavability, fiber environment, etc.).

Since 2023, he has also been Professor of Anatomy at the University of Lyon 1 and Deputy Head of Department of the Cranial Tumor and Vascular Neurosurgery Department. He regularly supervises Masters and thesis students on these areas of research at the intersection of surgery, anatomy and imaging.

Research focus

• Tractography of cerebral white fibers
• New surgical approaches to the skull base
• Advanced brain tumor surgery technique
• Anatomy of the skull and brain
• High resolution MRI

NATIONAL COLLABORATIONS 

• Brain imaging lab, U1253, Tours, France, https://ibrain.univ-tours.fr/english-version

INTERNATIONAL COLLABORATIONS 

• The Stanford Neurosurgical Training and Innovation Center, Stanford, CA, USA, https://med.stanford.edu/neurosurgery/research/SNFTVR_Lab.html
• The Surgical Neuroanatomy Lab, University of Pittsburgh Medical Center (UPMC), Pittsburgh, PA, USA, https://www.neurosurgery.pitt.edu/research/labs/surgical-neuroanatomy 

1. Ng S, Lima Maldonado I, Destrieux C, et al. Magnetic Resonance Diffusion Tractography of Brain White Matter tracts-An Educational 3-Dimensional Stereoscopic Overview for Operative Planning and Mapping in Brain Tumor Surgery: 3-Dimensional Operative Video. Oper Neurosurg Hagerstown Md. 2022;23(3):e177. doi:10.1227/ons.0000000000000306

2. Dauleac C, Frindel C, Mertens P, Jacquesson T, Cotton F. Overcoming challenges of the human spinal cord tractography for routine clinical use: a review. Neuroradiology. 2020;62(9):1079-1094. doi:10.1007/s00234-020-02442-8

3. Simon E, Beuriat PA, Delabar V, Jouanneau E, Fernandez-Miranda J, Jacquesson T. Cranial and Cerebral Anatomic Key Points for Neurosurgery: A New Educational Insight. Oper Neurosurg Hagerstown Md. 2022;22(1):e18-e27. doi:10.1227/ONS.0000000000000016

4. Jacquesson T, Yeh FC, Panesar S, et al. Full tractography for detecting the position of cranial nerves in preoperative planning for skull base surgery: technical note. J Neurosurg. 2020;132(5):1642-1652. doi:10.3171/2019.1.JNS182638

5. Jacquesson T, Cotton F, Attyé A, et al. Probabilistic Tractography to Predict the Position of Cranial Nerves Displaced by Skull Base Tumors: Value for Surgical Strategy Through a Case Series of 62 Patients. Neurosurgery. 2019;85(1):E125-E136. doi:10.1093/neuros/nyy538

6. Jacquesson T, Frindel C, Kocevar G, et al. Overcoming Challenges of Cranial Nerve Tractography: A Targeted Review. Neurosurgery. 2019;84(2):313-325. doi:10.1093/neuros/nyy229

7. Jacquesson T, Berhouma M, Tringali S, Simon E, Jouanneau E. Which Routes for Petroclival Tumors? A Comparison Between the Anterior Expanded Endoscopic Endonasal Approach and Lateral or Posterior Routes. World Neurosurg. 2015;83(6):929-936. doi:10.1016/j.wneu.2015.02.003

8. Jacquesson T, Simon E, Berhouma M, Jouanneau E. Anatomic comparison of anterior petrosectomy versus the expanded endoscopic endonasal approach: interest in petroclival tumors surgery. Surg Radiol Anat SRA. 2015;37(10):1199-1207. doi:10.1007/s00276-015-1497-5

9. Jacquesson T, Simon E, Dauleac C, Margueron L, Robinson P, Mertens P. Stereoscopic three-dimensional visualization: interest for neuroanatomy teaching in medical school. Surg Radiol Anat SRA. 2020;42(6):719-727. doi:10.1007/s00276-020-02442-6

10. Jacquesson T, Mertens P, Berhouma M, Jouanneau E, Simon E. The 360 photography: a new anatomical insight of the sphenoid bone. Interest for anatomy teaching and skull base surgery. Surg Radiol Anat SRA. 2017;39(1):17-22. doi:10.1007/s00276-016-1702-1