Dr Emilien BERNARD
Neurology department – movement disorders and neuromuscular pathologies
The neurology – movement disorders and muscular pathologies department is particularly involved in certain subspecialties of neurology: Parkinson’s disease and abnormal movements on the one hand; ALS (Amyotrophic Lateral Sclerosis or Charcot disease) and neuromuscular pathologies on the other hand.
The service is the subject of various labels which testify to its role as an expert, particularly in ALS as a rare disease reference center of which Dr Emilien BERNARD is the coordinator.
Themes
Research axis
Dr Emilien BERNARD is the coordinator of the rare disease reference center dedicated to Amyotrophic Lateral Sclerosis (ALS) and other rare motor neuron diseases in Lyon, the second French center in terms of clinical activity. Member of the FILSLAN office as well as the ACT4ALS-MND clinical research network (labeled F-CRIN), he participates in numerous international clinical trials on ALS. As part of a consortium between HCL, Axoltis Pharma and Active Biomarkers, funded by the AURA region, Dr BERNARD is the coordinating investigator of a national multicenter study evaluating the usefulness of an innovative molecule targeting the blood barrier -encephalic. He is a member of the scientific council of ARSLA. Within its attached research unit (Institut NeuroMyoGène – Pascal LEBLANC) the genetic origins of the disease are being explored as well as the development of biomarkers. He has a particular interest in the clinical genetics of the disease: genetic counseling, monitoring of presymptomatic patients, treatment with antisense oligonucleotides, discovery of new causal genes or description of new phenotypes. Within the neuromuscular and motor neuron diseases department of the Pierre Wertheimer neurological hospital (unit 501) the arrival of gene therapy is being prepared, in particular for certain rare genetic forms of ALS, with a dedicated treatment room available, in accordance with the relevant legislation.
The research axes are:
- Amyotrophic Lateral Sclerosis
- Rare motor neuron diseases
- Clinical genetics of motor neuron diseases
- Biomarkers
- The development of innovative molecules
Publications
5. Comparative diagnosis interest of NfL and pNfH in CSF and plasma in a context of FTD-ALS spectrum.
Escal J, Fourier A, Formaglio M, Zimmer L, Bernard E, Mollion H, Bost M, Herrmann M, Ollagnon-Roman E, Quadrio I, Dorey JM.
J Neurol. 2022
