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Primary brain tumors in adults

Department of Cranial, General, Tumor, and Vascular Neurosurgery

The Department of General, Tumor, and Vascular Cranial Neurosurgery, led by Prof. Emmanuel Jouanneau, is one of three adult neurosurgery departments in Lyon and brings together expertise across various fields of cranial surgery.

Each neurosurgeon develops specialized expertise in a specific area to optimize the quality of patient care. Clinical activity is structured around five sub-specialty areas. The management of primary and secondary brain tumors is one of these areas. Highly specific intraoperative techniques—such as fluorescence-guided surgery, awake surgery for tumor resection, and intracavitary chemotherapy—are employed.

Dr. Thiébaud Picart and Dr. Clémentine Gallet, who work in partnership with him, lead this area of ​​specialization.

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neuro-ophtamologie
Pr-Claire-Haegelen

Dr Thiébaud PICART

Member of the CRCL team “Glioblastoma metabolism and heterogeneity, in 3D organoids”

Other team members:

– Dr. Clémentine Gallet (Hospital Practitioner) (CRCL “Glioblastoma metabolism and heterogeneity, in 3D organoids”)

Main collaborations :

  • Pr Bruno MONTCEL (CREATIS)
  • Dr Cédric RAY GARREAU (CREATIS)
  • Dr Arthur GAUTHERON (CREATIS)
  • Pr Julien JUNG (HCL)
  • Dr Mathilde BONNEFOND (CRNL)
  • Dr Denis SCHWARTZ (CRNL)

Research themes

  • Intraoperative imaging techniques (5-ALA fluorescence, optical and spectroscopic imaging) (PI: Dr Thiébaud Picart, Pr Bruno Montcel – CREATIS)
  • Surgical trials in neuro-oncology (PI: Dr Thiébaud Picart, Pr François Ducray – HCL)
  • Study of inter-tumoral and intra-tumoral heterogeneity of gliomas (PI: Dr Thiébaud Picart, Dr Erika Cosset – CRCL)
  • Study of glioma-neuron relationships – “Cancer Neuroscience” (PI: Dr Thiébaud Picart, Dr Erika Cosset – CRCL)

Main ongoing projects

  • GLIOMEG “Exploration and characterization of intratumoral electrophysiological heterogeneity in high-grade gliomas using magnetoencephalography and correlation of results with radiological profiles and tumor metabolism” (PI)
  • ALPHA-MEG “Dissecting the role and neural mechanisms of alpha rhythms using high-precision MEG, laminar recordings in patients, and neural network modeling” (co-PI)
  • HYPERPROBE “Transforming brain surgery by advancing functional-guided neuronavigational imaging” (co-PI)
  • RESURGE “Role of surgery in the management of progressive glioblastoma” (Partner)
  • 5. SONOBIRD “Ultrasound-mediated blood-brain barrier opening in patients treated for recurrent glioblastoma” (Partner)

Main national and international collaborations

NATIONAL COLLABORATIONS 

  • Paris (Pitié-Salpêtrière Hospital: Dr. Bertrand Mathon, Prof. Alexandre Carpentier)
  • RENOCLIP-LOC Network: INCa-accredited network of centers for rare central nervous system cancers

INTERNATIONAL COLLABORATIONS 

  • Zurich, Switzerland (Universitätsspital Zürich: Dr Emilie LE RHUN)
  • Bern, Switzerland (Universitätsspital Bern: Pr Philippe SCHUCHT)
  • San Francisco, USA (UCSF: Professor Shawn HERVEY JUMPER)

Publications

1. Picart T, Pallud J, Berthiller J, et al. Use of 5-ALA fluorescence-guided surgery versus white-light conventional microsurgery for the resection of newly diagnosed glioblastomas (RESECT study): a French multicenter randomized phase III study. J Neurosurg. 2024;140(4):987-1000. doi:10.3171/2023.7.JNS231170

2. Picart T, Poncet D, Barritault M, et al. Molecular Characterization of Adult Tumors Diagnosed as Cerebellar Glioblastomas Identifies Subgroups Associated With Prognosis. Am J Surg Pathol. 2023;47(1):131-144. doi:10.1097/PAS.0000000000001996

3. Picart T, Herbet G, Moritz-Gasser S, Duffau H. Iterative Surgical Resections of Diffuse Glioma With Awake Mapping: How to Deal With Cortical Plasticity and Connectomal Constraints? Neurosurgery. 2019;85(1):105-116. doi:10.1093/neuros/nyy218

4. Picart T, Hervey-Jumper S. Central nervous system regulation of diffuse glioma growth and invasion: from single unit physiology to circuit remodeling. J Neurooncol. 2024;169(1):1-10. doi:10.1007/s11060-024-04719-x

5. Picart T, Gautheron A, Caredda C, et al. Fluorescence-Guided Surgical Techniques in Adult Diffuse Low-Grade Gliomas: State-of-the-Art and Emerging Techniques: A Systematic Review. Cancers. 2024;16(15):2698. doi:10.3390/cancers16152698

6. Picart T, Dumot C, Guyotat J, et al. Clinical and pathological impact of an optimal assessment of brain invasion for grade 2 meningioma diagnosis: lessons from a series of 291 cases. Neurosurg Rev. 2022;45(4):2797-2809. doi:10.1007/s10143-022-01792-6

7. Picart T, Barritault M, Poncet D, et al. Characteristics of diffuse hemispheric gliomas, H3 G34-mutant in adults. Neuro-Oncol Adv. 2021;3(1):vdab061. doi:10.1093/noajnl/vdab061

8. Aggarwal A, Youngblood MW, Picart T, et al. Meningioma cell reprogramming and microenvironment interactions underlie brain invasion. Neuro-Oncol. 2026;28(4):926-938. doi:10.1093/neuonc/noaf292

9. Koldeweij M, Picart T, Thomas L, et al. Dynamic susceptibility contrast MRI-derived oxygen metabolism and perfusion metrics for distinguishing radiation necrosis from tumor progression in irradiated brain metastases. Diagn Interv Imaging. 2026;107(6):229-238. doi:10.1016/j.diii.2026.01.002

10. Gkasdaris G, Berthiller J, Guyotat J, et al. Is Carmustine Wafer Implantation in Progressive High-Grade Gliomas a Relevant Therapeutic Option? Complication Rate, Predictors of Complications and Onco-Functional Outcomes in a Series of 53 Cases. Cancers. 2024;16(20):3465. doi:10.3390/cancers16203465